Cardiac tumour 

  • primary tumour 

benign tumour-myxoma,Rhabdomyoma

  • secondary tumour-most common
  • most common primary malignant tumour- angiosarcoma
  • most common primary benign tumour in adult- myxoma
  • most common primary benign tumour in child -rhabdomyosarcoma
  • myxoma-cell of origin-mesenchymal stem cell located on atrium.
  • in myxoma obstruction in ventricle.
  • clinical features of myxoma
  • embolism, fever ,Ball valve appearance.
  • microscopic appearance-presence of lipid cell in atrial myxoma
  • sporadic in nature- in 90% cases and single in origin
  • familial in nature-10% individual arise bilaterally .
  • familial type cause carney syndrome

carney syndrome cause classical triad

  • present of myxoma
  • hyperpigmentation of skin
  • endocrine over activity

carney syndrome can also be associated with mccune Albright syndrome and associated with mutation of PRAKAR

Rhabdomyoma

  • arise from ventricle.
  • occur in children
  • spider cell appearance due to glycogen.